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📌 Genes 28393 ▶
▸ Genes (81)
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brain-derived neurotrophic factor (39)neuroplasticity (32)exercise (20)neurobiology (19)neurotoxicity (18)trkb (16)traditional chinese medicine (15)genetics (15)neurotrophic factors (14)hippocampal (13)central nervous system (12)neuroprotective (11)gut-brain axis (10)neurology (10)stroke (10)obesity (9)neurotrophic (9)psychology (9)dementia (9)zebrafish (8)bipolar disorder (8)neurotrophins (8)blood-brain barrier (8)aging (7)anti-inflammatory (7)neuropsychiatric disorders (7)memory (7)nanoparticles (7)neuropathic pain (7)neurotransmission (6)neurological disorders (6)mental health (6)neurotrophin (6)rats (6)stem cells (6)neuromodulation (6)astrocytes (6)neurodevelopmental disorders (6)psychiatry (6)cns (5)neuronal cells (5)meta-analysis (5)bioavailability (5)biochemistry (5)pathology (5)psychedelics (5)probiotics (5)amyloid-β (5)epilepsy (5)neurodevelopment (5)polymorphism (5)akt (5)aerobic exercise (5)astrocyte (4)nutrition (4)metabolomics (4)toxicity (4)neuroimmune (4)amyloid beta 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⚗️ Metals 1041 ▶
▸ Metals — Other (620)
neuroscience (64)cognitive function (30)synaptic plasticity (25)stress (15)antidepressant (14)pharmacology (11)cognitive dysfunction (10)toxicology (9)cognition (9)serotonin (8)major depressive disorder (7)molecular biology (7)spinal cord injury (7)prefrontal cortex (7)chronic stress (6)autism spectrum disorder (6)chronic pain (6)exosomes (6)ptsd (6)cognitive (6)irisin (5)pregnancy (5)memory impairment (5)network pharmacology (5)cognitive performance (5)endoplasmic reticulum stress (5)neuropharmacology (5)environmental enrichment (4)homeostasis (4)oncology (4)neuroprotective effects (4)traumatic brain injury (4)molecular mechanisms (4)depressive disorder (4)cardiovascular (4)psychopharmacology (4)neuroregeneration (4)resveratrol (4)post-traumatic stress disorder (4)chitosan (4)affective disorders (3)osteoporosis (3)insomnia (3)high-intensity interval training (3)neurobiological mechanisms (3)serum (3)treatment-resistant depression (3)mirna (3)nerve regeneration (3)animal model 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interval training (1)prosopis cineraria (1)psychosis (1)constipation (1)psychedelic compounds (1)delphinidin (1)myostatin (1)triterpenoid saponins (1)limbic structures (1)osteoblast (1)bdnf expression (1)poly(lactic-co-glycolic acid) (1)korean population (1)neuroimmune crosstalk (1)chronic diseases (1)low birthweight (1)α7 nicotinic acetylcholine receptor (1)protein quality control (1)peptide hydrogel (1)fecal calprotectin (1)metabolic adaptation (1)single-cell transcriptomics (1)cell differentiation (1)neurogenic bladder (1)hippocampal synaptic proteins (1)chemoresistance (1)herb pair (1)chronotropic incompetence (1)autism-like behavior (1)testicular health (1)aggressive behavior (1)allodynia (1)obstructive sleep apnea (1)opioid overdose (1)gold coast criteria (1)n-methyl-d-aspartate receptor (1)psychological stress (1)betulinic acid (1)retinal degeneration (1)depressive pathologies (1)traumatic event (1)ros (1)extremely low-frequency electromagnetic field (1)cognitive impairments 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📌 LLM 852 ▶
▸ LLM (77)
bdnf (116)neuroprotection (67)depression (63)neuroinflammation (53)neurotrophic factor (49)alzheimer's disease (44)oxidative stress (40)anxiety (32)inflammation (28)apoptosis (22)cognitive impairment (20)biomarkers (16)neurodegeneration (16)gene expression (15)parkinson's disease (15)hippocampus (15)cognitive decline (15)brain (15)gut microbiota (13)schizophrenia (13)microglia (11)therapeutic target (11)neurogenesis (11)biomarker (10)creb (9)signaling pathway (9)huntington's disease (8)animal study (8)bdnf/trkb (8)neurodegenerative disease (7)neuron (7)hpa axis (5)cerebral ischemia (5)autophagy (4)in vitro (4)nrf2 (4)mitochondrial dysfunction (4)hiv (4)synaptic remodeling (3)mapk (3)longitudinal study (3)gut (2)preclinical study (2)synaptogenesis (2)cerebrospinal fluid (2)mtor (2)plasma (2)epigenetic mechanisms (2)multiple sclerosis (2)dna damage (2)erk1/2 (2)nf-κb (2)amyloid clearance (1)mechanotransduction (1)neurotrophic effects (1)cholinergic neurotransmission (1)alzheimer (1)neuropsychiatric disorder (1)feature selection (1)brain injury (1)neural stem cell (1)neuroinflammatory signaling (1)review (1)microbial metabolite (1)friedreich's ataxia (1)nrf2/are (1)non-alcoholic steatohepatitis (1)clinical observation (1)cerebellar granule neurons (1)pi3k/akt (1)exposome (1)neurocognitive performance (1)cohort study (1)stress response (1)erk/creb (1)epigenetic regulation (1)neuroendocrine signaling (1)
🦠 Diseases 57 ▶
▸ Diseases — Other (15)
neurodegenerative diseases (15)neurodegenerative disorder (10)neurodegenerative disorders (10)diabetes (5)cancer (3)type 2 diabetes (2)lung cancer (2)alzheimer disease (2)type 2 diabetes mellitus (2)type 3 diabetes (1)neurodegenerative (1)non-small cell lung cancer (1)diabetes mellitus (1)anticancer (1)gestational diabetes mellitus (1)
⚙️ Mechanisms 56 ▶
▸ Mechanisms — Other (43)
signaling pathways (6)signaling (4)mitochondrial dynamics (3)epigenetics (2)mitochondrial (2)bdnf signaling (2)mitochondrial biogenesis (1)epigenetic (1)crf signaling (1)pi3k/akt signaling pathway (1)oxidative dna damage (1)mapk/erk/jnk signaling pathways (1)bdnf/trkb signaling (1)biological signaling pathways (1)mitochondrial fatty acid β-oxidation (1)mitochondrial fusion (1)wnt signaling (1)nf-kb signaling (1)neural signaling (1)akt signaling pathway (1)mitochondrial quality (1)pi3k/akt/mtor signaling pathway (1)mitochondrial functions (1)camp/pka signaling pathway (1)cholinergic signaling (1)neuroplastic signaling (1)cellular signaling (1)neurotrophin signaling (1)metabolite signaling (1)serotonergic signaling (1)mitochondria (1)epigenetic modifications (1)endocrine signaling (1)insulin signaling (1)ng2 signaling (1)pacap signaling (1)pi3k/akt/bdnf signaling (1)bdnf-trkb signaling pathway (1)camp signaling (1)mitochondrial energy metabolism (1)pain signaling (1)calcium signaling (1)neuroimmune signaling (1)
🎯 Targets 22 ▶
▸ Targets — Other (13)
micrornas (4)microrna (3)maternal separation (2)lncrna (2)maternal immune activation (2)maternal exercise (2)microrna-34a (1)maternal (1)mtor pathway (1)rna (1)dna methylation (1)mrna (1)fibrinolytic enzymes (1)
🧬 Activities 20 ▶
▸ Activities — Other (10)
antioxidant (11)sensory nerves (1)antioxidant activity (1)pet imaging (1)in vivo imaging (1)bioluminescence imaging (1)sensory neurotoxicity (1)neuroimaging (1)antioxidants (1)antioxidant properties (1)
🔗 Ligands 19 ▶
▸ Ligands — Other (12)
ketamine (4)monoamine deficiency (2)monoaminergic (2)dopamine (2)dopaminergic neurons (2)dopaminergic neuron (1)histaminergic transmission (1)esketamine (1)monoamine (1)dopaminergic (1)methamphetamine (1)histamine (1)
🧠 Concepts 5 ▶
▸ Concepts — Other (4)
metabolism (2)immunometabolism (1)brain metabolism (1)energy metabolism (1)
💊 Drugs 4 ▶
▸ Drugs — Other (3)
quercetin (2)oxaliplatin (1)paclitaxel (1)

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Microglial reactivity and neuroinflammation-driven changes in motivational behaviors are regulated by Orai1 calcium channels.

Kaitlyn E DeMeulenaere, Rogan A Grant, Megan E Martin +4 more · 2026 · Science signaling · Science · added 2026-04-24
Microglia are the brain's resident immune cells that respond to injury and disease by transitioning between homeostatic and reactive states. These cell state transitions determine whether microglia pr Show more
Microglia are the brain's resident immune cells that respond to injury and disease by transitioning between homeostatic and reactive states. These cell state transitions determine whether microglia promote or resolve inflammation in the central nervous system (CNS). In this study, we explored the role of Ca Show less
no PDF DOI: 10.1126/scisignal.ady8398
BDNF calcium channels central nervous system cns immune cells inflammation microglia motivational behaviors