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▸ Metals — Other (620)
neuroscience (64)cognitive function (30)synaptic plasticity (25)stress (15)antidepressant (14)pharmacology (11)cognitive dysfunction (10)toxicology (9)cognition (9)serotonin (8)major depressive disorder (7)molecular biology (7)spinal cord injury (7)prefrontal cortex (7)chronic stress (6)autism spectrum disorder (6)chronic pain (6)exosomes (6)ptsd (6)cognitive (6)irisin (5)pregnancy (5)memory impairment (5)network pharmacology (5)cognitive performance (5)endoplasmic reticulum stress (5)neuropharmacology (5)environmental enrichment (4)homeostasis (4)oncology (4)neuroprotective effects (4)traumatic brain injury (4)molecular mechanisms (4)depressive disorder (4)cardiovascular (4)psychopharmacology (4)neuroregeneration (4)resveratrol (4)post-traumatic stress disorder (4)chitosan (4)affective disorders (3)osteoporosis (3)insomnia (3)high-intensity interval training (3)neurobiological mechanisms (3)serum (3)treatment-resistant depression (3)mirna (3)nerve regeneration (3)animal model 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syndrome (1)seizure susceptibility (1)immune reactions (1)tumor necrosis factor alpha (1)mirnas (1)menopausal (1)microbiota dysbiosis (1)bed rest (1)nicotine (1)bone loss (1)cubosome formulation (1)post traumatic stress disorder (1)vascular dysfunction (1)hyperandrogenism (1)pd-1 (1)hippocampal neuronal apoptosis (1)prenatal exposure (1)pyroptosis (1)withaferin a (1)glycolysis (1)microenvironment (1)redox balance (1)circadian rhythm (1)olfactory exposure (1)nose-to-brain delivery (1)neurocognitive outcomes (1)sex differences (1)neuro-osteogenic microenvironment (1)acute ischemic stroke (1)psychedelic drugs (1)sinomenine (1)secretory protein (1)maladaptive neuroplasticity (1)facial recognition (1)stress disorder (1)carnosine (1)synaptic deficits (1)mir-146a-3p (1)regulation (1)ferritin (1)protein secretion (1)scopolamine-induced amnesia (1)randomized controlled trial (1)principal component analysis (1)appetite regulation (1)psychiatric comorbidities (1)environmental toxicology (1)gynecology (1)hif-1α-epo/camp-creb-bdnf pathway (1)depressive states (1)learning process (1)neural regeneration (1)cardiac arrest (1)psychological outcomes (1)affective states (1)gut dysbiosis (1)long non-coding rnas (1)prefrontal-limbic connectivity (1)psychological reaction (1)extremely low-frequency magnetic field (1)clinical assessment (1)microglial exosomes (1)neurotoxicology (1)epileptogenesis (1)clinical trial (1)anabolic-androgenic steroid (1)ethnic medicine (1)mitochondrial calcium uniporter (1)weight loss (1)amitriptyline (1)stress responsivity (1)serotonergic circuit (1)lps-induced depression (1)locomotion (1)steroidal saponin (1)aquatic organisms (1)correlation (1)drug response (1)transcriptomic (1)long non-coding rna (1)rheumatoid arthritis (1)rem theta (1)absorption (1)chronic heart failure (1)fentanyl administration (1)molecular toxicology (1)vascular cognitive impairment (1)motor impairment (1)adipose-derived stem cells (1)neuro-related disorders (1)emotional regulation (1)restraint stress (1)regenerative capabilities (1)antinociceptive (1)cerebral palsy (1)cerebral infarction (1)normal pressure hydrocephalus (1)positron emission tomography (1)bioengineered delivery system (1)adenosine (1)connexin43 (1)immunoregulation (1)comorbid (1)cerebrovascular disease (1)in silico (1)moderate-intensity continuous training (1)cognitive improvement (1)stress-induced depressive behaviors (1)drug delivery (1)lycopene delivery (1)host-virus interactions (1)phosphatidic acid (1)sirt1 (1)neuroserpin (1)heat stress (1)macular degeneration (1)medial prefrontal cortex (1)intranasal drug delivery (1)early diagnosis (1)rem sleep behavior disorder (1)seizures (1)psychosocial (1)prenatal supplementation (1)adeno-associated virus (1)neurotoxic effects (1)proanthocyanidins (1)neurocognitive (1)anti-inflammatory effects (1)gestational opioid exposure (1)nociceptive sensitization (1)stress axis regulation (1)anthocyanins (1)pruritus (1)phlorotannin (1)high intensity interval training (1)prosopis cineraria (1)psychosis (1)constipation (1)psychedelic compounds (1)delphinidin (1)myostatin (1)triterpenoid saponins (1)limbic structures (1)osteoblast (1)bdnf expression (1)poly(lactic-co-glycolic acid) (1)korean population (1)neuroimmune crosstalk (1)chronic diseases (1)low birthweight (1)α7 nicotinic acetylcholine receptor (1)protein quality control (1)peptide hydrogel (1)fecal calprotectin (1)metabolic adaptation (1)single-cell transcriptomics (1)cell differentiation (1)neurogenic bladder (1)hippocampal synaptic proteins (1)chemoresistance (1)herb pair (1)chronotropic incompetence (1)autism-like behavior (1)testicular health (1)aggressive behavior (1)allodynia (1)obstructive sleep apnea (1)opioid overdose (1)gold coast criteria (1)n-methyl-d-aspartate receptor (1)psychological stress (1)betulinic acid (1)retinal degeneration (1)depressive pathologies (1)traumatic event (1)ros (1)extremely low-frequency electromagnetic field (1)cognitive impairments (1)chronic toxoplasmosis (1)dacomitinib (1)serotonin 5-ht2a receptor (1)pulmonary fibrosis (1)psychostimulant (1)chronic unpredictable mild stress (1)tobacco smoke (1)radiofrequency electromagnetic fields (1)fetal brain development (1)sedative-hypnotic effect (1)social buffering (1)depressive disorders (1)epigenetic dysregulation (1)neuroimmune circuits (1)childhood growth restriction (1)resolvin d1 (1)molecular design (1)glp-1 receptor agonists (1)brain-gut homeostasis (1)neurotrophic adaptation (1)liver failure (1)creb pathway (1)diclofenac (1)n6-methyladenosine (1)immune mechanisms (1)laminin (1)cerebrovascular accidents (1)suicide attempt (1)neural repair (1)synaptic (1)adverse outcome pathway (1)opioid receptors (1)memory impairments (1)fibrotic remodeling (1)neuronal communication (1)appetite control (1)outcomes (1)hypothalamus-pituitary-adrenal axis (1)serum bdnf levels (1)lung homeostasis (1)perioperative neurocognitive disorders (1)cognitive training (1)melatonin receptor (1)adolescent social isolation stress (1)cognitive therapy (1)fear memory (1)osseointegration (1)musculoskeletal system (1)colitis (1)autoimmune uveitis (1)light treatment (1)cerebral protection (1)neurotrophic dysregulation (1)ingredient (1)developmental neurotoxicology (1)transcriptional changes (1)neurosteroids (1)environmental conditions (1)orthostatic hypotension (1)pathological microenvironment (1)autologous serum (1)physiological resilience (1)spatial transcriptomics (1)function recovery (1)age-related macular degeneration (1)seizure (1)mangiferin (1)preclinical models (1)herpes simplex virus (1)exosome-based therapy (1)peptides (1)melanocortin (1)tau phosphorylation (1)tumor necrosis factor (1)eicosapentaenoic acid (1)neural circuit (1)hypothalamic-pituitary-adrenal axis (1)brain structure (1)phosphatidylserine (1)irák1 (1)colorectal cancer (1)perinatal depression (1)learning ability (1)allostatic load (1)adolescent depression (1)creatine supplementation (1)affective dysfunction (1)non-pharmacological interventions (1)personal care products (1)diagnosis (1)unfolded protein response (1)antidepressant mechanisms (1)cerebral hemorrhage (1)autophagic pathway (1)nanocomposite hydrogel (1)causal relationship (1)fear extinction (1)neuropeptide s (1)nociceptive responses (1)dpd-4 inhibitors (1)traumatic stress disorder (1)colon cancer (1)tau hyperphosphorylation (1)tyrosine kinase receptor b (1)ecosystems (1)reproductive physiology (1)stress regulation (1)motor learning (1)disease-syndrome combined model (1)methionine-choline-deficient diet (1)s-nitrosylation (1)neurocognitive disorders (1)postmenopausal women (1)neural recovery (1)kaempferol (1)postoperative delirium (1)receptor (1)social cognition (1)neurocognition (1)environmental (1)hcortisolaemia (1)integrated stress response (1)systemic effects (1)antiretroviral therapy (1)adenosine receptor (1)late-life cognitive decline (1)traumatic memories (1)energy homeostasis (1)antidepressant effect (1)physiological adaptations (1)inflammatory responses (1)tissue architecture (1)vascularization (1)neuroimmune responses (1)human respiratory syncytial virus (1)vision loss (1)rapid antidepressant effects (1)tau pathology (1)drug release (1)signal peptide (1)noncommunicable diseases (1)electrospun (1)alcohol-induced cognitive impairment (1)vasoactive intestinal polypeptide (1)cognitive behavior (1)hypothalamic pituitary adrenal axis (1)machine learning (1)hypothalamic-pituitary adrenal axis (1)parkinsonism (1)cognitive resilience (1)impairment (1)experimental autoimmune uveoretinitis (1)precursor state (1)hmg-coa reductase inhibitors (1)tumor necrosis factor-α (1)relationship (1)cognitive aging (1)clinical psychology (1)antidepressant activity (1)optic nerve injury (1)mechanistic (1)vascular maturation (1)biomechanics (1)aerospace medicine (1)oncogenic drivers (1)differentiation (1)resistance training (1)paraventricular nucleus (1)ecotoxicity (1)synaptic homeostasis (1)environmental concern (1)bdnf/creb pathway (1)creb phosphorylation (1)mood dysregulation (1)nitrous oxide (1)dentate gyrus (1)paternal exposure (1)behavioral despair (1)nicotine exposure (1)lactobacillus plantarum (1)electroacupuncture (1)female mice (1)fetal neural development (1)tropomyosin receptor kinase b (1)environmental contaminants (1)differentiation protocols (1)magnetic resonance imaging (1)reward processing (1)arsenic (1)steroid effects (1)diosgenin (1)stress hormone (1)oral administration (1)hemorheology (1)synaptic models (1)reversal learning (1)synaptic signaling (1)cognitive outcomes (1)presynaptic (1)magnetic field exposure (1)ischemia reperfusion injury (1)nitric oxide (1)toxoplasmosis (1)tyrosine kinase inhibitors (1)acute hepatitis (1)glucagon-like peptide-1 receptor agonists (1)somatosensory cortex (1)serotonin pathway (1)biological effects (1)cyanidin (1)breast cancer (1)
📌 LLM 852 ▶
▸ LLM (77)
bdnf (116)neuroprotection (67)depression (63)neuroinflammation (53)neurotrophic factor (49)alzheimer's disease (44)oxidative stress (40)anxiety (32)inflammation (28)apoptosis (22)cognitive impairment (20)biomarkers (16)neurodegeneration (16)gene expression (15)parkinson's disease (15)hippocampus (15)cognitive decline (15)brain (15)gut microbiota (13)schizophrenia (13)microglia (11)therapeutic target (11)neurogenesis (11)biomarker (10)creb (9)signaling pathway (9)huntington's disease (8)animal study (8)bdnf/trkb (8)neurodegenerative disease (7)neuron (7)hpa axis (5)cerebral ischemia (5)autophagy (4)in vitro (4)nrf2 (4)mitochondrial dysfunction (4)hiv (4)synaptic remodeling (3)mapk (3)longitudinal study (3)gut (2)preclinical study (2)synaptogenesis (2)cerebrospinal fluid (2)mtor (2)plasma (2)epigenetic mechanisms (2)multiple sclerosis (2)dna damage (2)erk1/2 (2)nf-κb (2)amyloid clearance (1)mechanotransduction (1)neurotrophic effects (1)cholinergic neurotransmission (1)alzheimer (1)neuropsychiatric disorder (1)feature selection (1)brain injury (1)neural stem cell (1)neuroinflammatory signaling (1)review (1)microbial metabolite (1)friedreich's ataxia (1)nrf2/are (1)non-alcoholic steatohepatitis (1)clinical observation (1)cerebellar granule neurons (1)pi3k/akt (1)exposome (1)neurocognitive performance (1)cohort study (1)stress response (1)erk/creb (1)epigenetic regulation (1)neuroendocrine signaling (1)
🦠 Diseases 57 ▶
▸ Diseases — Other (15)
neurodegenerative diseases (15)neurodegenerative disorder (10)neurodegenerative disorders (10)diabetes (5)cancer (3)type 2 diabetes (2)lung cancer (2)alzheimer disease (2)type 2 diabetes mellitus (2)type 3 diabetes (1)neurodegenerative (1)non-small cell lung cancer (1)diabetes mellitus (1)anticancer (1)gestational diabetes mellitus (1)
⚙️ Mechanisms 56 ▶
▸ Mechanisms — Other (43)
signaling pathways (6)signaling (4)mitochondrial dynamics (3)epigenetics (2)mitochondrial (2)bdnf signaling (2)mitochondrial biogenesis (1)epigenetic (1)crf signaling (1)pi3k/akt signaling pathway (1)oxidative dna damage (1)mapk/erk/jnk signaling pathways (1)bdnf/trkb signaling (1)biological signaling pathways (1)mitochondrial fatty acid β-oxidation (1)mitochondrial fusion (1)wnt signaling (1)nf-kb signaling (1)neural signaling (1)akt signaling pathway (1)mitochondrial quality (1)pi3k/akt/mtor signaling pathway (1)mitochondrial functions (1)camp/pka signaling pathway (1)cholinergic signaling (1)neuroplastic signaling (1)cellular signaling (1)neurotrophin signaling (1)metabolite signaling (1)serotonergic signaling (1)mitochondria (1)epigenetic modifications (1)endocrine signaling (1)insulin signaling (1)ng2 signaling (1)pacap signaling (1)pi3k/akt/bdnf signaling (1)bdnf-trkb signaling pathway (1)camp signaling (1)mitochondrial energy metabolism (1)pain signaling (1)calcium signaling (1)neuroimmune signaling (1)
🎯 Targets 22 ▶
▸ Targets — Other (13)
micrornas (4)microrna (3)maternal separation (2)lncrna (2)maternal immune activation (2)maternal exercise (2)microrna-34a (1)maternal (1)mtor pathway (1)rna (1)dna methylation (1)mrna (1)fibrinolytic enzymes (1)
🧬 Activities 20 ▶
▸ Activities — Other (10)
antioxidant (11)sensory nerves (1)antioxidant activity (1)pet imaging (1)in vivo imaging (1)bioluminescence imaging (1)sensory neurotoxicity (1)neuroimaging (1)antioxidants (1)antioxidant properties (1)
🔗 Ligands 19 ▶
▸ Ligands — Other (12)
ketamine (4)monoamine deficiency (2)monoaminergic (2)dopamine (2)dopaminergic neurons (2)dopaminergic neuron (1)histaminergic transmission (1)esketamine (1)monoamine (1)dopaminergic (1)methamphetamine (1)histamine (1)
🧠 Concepts 5 ▶
▸ Concepts — Other (4)
metabolism (2)immunometabolism (1)brain metabolism (1)energy metabolism (1)
💊 Drugs 4 ▶
▸ Drugs — Other (3)
quercetin (2)oxaliplatin (1)paclitaxel (1)

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2 articles with selected tags

Betulinic acid increases brain-derived neurotrophic factor expression via the PKA, NMDA receptor, and calcineurin pathways in cultured cortical neurons.

Mamoru Fukuchi, Natsumi Maeda, Sachie Hoshino +2 more · 2026 · Journal of natural medicines · Springer · added 2026-04-24
no PDF DOI: 10.1007/s11418-026-02025-6
BDNF betulinic acid brain-derived neurotrophic factor calcineurin cortical neurons neurotrophic factor nmda receptor pka

Rational Design of Dual-Targeting Novel GPE-Derived Oligopeptide Conjugates for Alzheimer's Disease: Synergistic Inhibition of Excitotoxicity and Oxidative Stress.

Dan Yang, Yilin Song, Shihui Yu +2 more · 2026 · ACS chemical neuroscience · ACS Publications · added 2026-04-24
Alzheimer's disease (AD) presents a critical therapeutic gap, necessitating novel multitarget strategies. Excitotoxicity via NMDA receptor overactivation and oxidative stress is a key driver of Tau hy Show more
Alzheimer's disease (AD) presents a critical therapeutic gap, necessitating novel multitarget strategies. Excitotoxicity via NMDA receptor overactivation and oxidative stress is a key driver of Tau hyperphosphorylation and neuronal loss. While the tripeptide Gly-Pro-Glu (GPE) derived from IGF-1 exhibits NMDA receptor antagonism, its clinical potential is limited by poor blood-brain barrier penetration and rapid hydrolysis. Herein, we rationally designed three novel GPE-derived oligopeptide conjugates (SAC-PE, SPE, and SAR-SPE) by replacing the N-terminal glycine with antioxidant moieties (( Show less
no PDF DOI: 10.1021/acschemneuro.5c00871
BDNF alzheimer's disease blood-brain barrier excitotoxicity neuroprotection nmda receptor oxidative stress peptide design