👤 Michaela Liedtke

The treatment of Waldenström macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) has evolved to include several new options. The NCCN Guidelines for WM/LPL provide a framework on which to base decisions regarding diagnosis, treatment, assessment of response to treatment, and follow-up of both newly diagnosed and previously treated WM/LPL. Show less

Epithelialized somites form repeatedly from the unsegmented presomitic mesoderm (PSM) in the tailbud of vertebrate embryos. Mutant analysis has shown that the Delta-Notch pathway is essential for the temporal and spatial control of somite formation. Several components of this pathway show cyclic transcription, which is driven by a molecular oscillator. This oscillator is thought to act similarly in different vertebrates. In this study, we used the Japanese Medaka (Oryzias latipes) to examine the expression of three factors of the Delta-Notch cascade that are known to show cyclic expression in the PSM of higher vertebrates. We report that in contrast to the situation in mice, lunatic fringe (lfng) in medaka is expressed in a non-dynamic fashion in the rostral halves of the formed somites and the anteriormost PSM. On the other hand, her7, a member of the hairy/Enhancer-of-split related (Her) gene family, shows cyclic expression in the medaka PSM. Although this is similar in zebrafish, there are important differences in the distribution of transcripts in the PSM indicating different modes of regulation in both fish species. Finally, we show that hey1, another Delta-Notch regulated bHLH gene, is dynamically expressed in the PSM of medaka, similar to hey1 in zebrafish and the hey2 orthologs in mice and chicken. Interestingly, medaka hey1 is also expressed in the dorsal aorta and the heart, two tissues where hey2, but not hey1, is expressed in zebrafish. This shows that several components of the Delta-Notch pathway are differently regulated during somitogenesis in different species. Show less