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A cell-adapted SARS-CoV-2 mutant, showing a deletion in the spike protein spanning the furin cleavage site, has reduced virulence at the lung level in K18-hACE2 mice.

Fabrizia Valleriani, Chiara Di Pancrazio, Massimo Spedicato +17 more · 2024 · Virology · Elsevier · added 2026-04-24

Here we investigated the virulence properties of a unique cell-adapted SARS-CoV-2 mutant showing a ten-amino acid deletion encompassing the furin cleavage site of the spike protein (Δ

no PDF DOI: 10.1016/j.virol.2024.109997

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👤 Francesco Bencivenga

A cell-adapted SARS-CoV-2 mutant, showing a deletion in the spike protein spanning the furin cleavage site, has reduced virulence at the lung level in K18-hACE2 mice.