While the diagnosis of frontotemporal dementia (FTD) is based mostly on clinical features, [ The purpose of this study is to conduct a systematic review and meta-analysis on the diagnostic performance Show more
While the diagnosis of frontotemporal dementia (FTD) is based mostly on clinical features, [ The purpose of this study is to conduct a systematic review and meta-analysis on the diagnostic performance of ASL MRI in patients with FTD and compare it with that of [ A systematic search of PubMed, Scopus, and Embase was conducted until March 13, 2024. Inclusion criteria were original articles, patients with FTD and/or its variants, use of ASL MR perfusion imaging with or without [ The quality of eligible studies was assessed by using the Quality Assessment of Diagnostic Accuracy Studies-2. Pooled sensitivity, specificity, and diagnostic odds ratio (DOR) for [ Seven eligible studies were identified, which included a total of 102 patients with FTD. Aside from some of the studies showing, at worst, an unclear risk of bias in patient selection, index test, flow, and timing, all studies showed low risk of bias and applicability concerns in all categories. Data from 4 studies were included in our meta-analysis for ASL MRI and 3 studies for [ The number of studies was relatively small, with a small sample size. The studies used different scanning protocols as well as a mix of diagnostic metrics, all of which might have introduced heterogeneity in the data. While ASL MRI performed worse than [ Show less