ObjectivesAs there is a lack of reports on the association between anti-lipoprotein lipase (anti-LPL) antibodies and dyslipoproteinemia, we aimed to analyse the association between anti-LPL antibodies Show more
ObjectivesAs there is a lack of reports on the association between anti-lipoprotein lipase (anti-LPL) antibodies and dyslipoproteinemia, we aimed to analyse the association between anti-LPL antibodies and the clinical and serological characteristics of patients with systemic lupus erythematosus (SLE) and cardiovascular (CV) events.MethodsEighty patients with SLE were examined for the presence of anti-LPL antibodies via western blotting. Data on laboratory findings and the occurrence of CV events were retrospectively collected and evaluated. Patients with SLE were classified into two groups according to the detection of anti-LPL antibodies: anti-LPL antibody-positive and antibody-negative.ResultsAnti-LPL antibody immunoglobulin G was detected in 28 patients with SLE (35.0%). Additionally, triglyceride levels tended to be higher in the anti-LPL antibody-positive group than in the anti-LPL antibody-negative group. The former exhibited significantly higher levels of serum albumin, anti-Smith antibody, and IgM than the latter. The incidence of CV events was higher in the anti-LPL antibody-positive group than in the anti-LPL antibody-negative group (35.7% vs 5.8%, Show less
Brown adipose tissue (BAT), a thermogenic tissue that plays an important role in systemic energy expenditure, has histological and functional sex differences. BAT thermogenic activity is higher in fem Show more
Brown adipose tissue (BAT), a thermogenic tissue that plays an important role in systemic energy expenditure, has histological and functional sex differences. BAT thermogenic activity is higher in female mice than in male mice. However, the molecular mechanism underlying this functional sex difference has not been fully elucidated. Herein, we demonstrate the role and mechanism of PGC-1α in this sex difference. Inducible adipocyte-specific PGC-1α knockout (KO) mice display mitochondrial morphological defects and decreased BAT thermogenesis only in females. Expression of carbohydrate response-element binding protein beta (Chrebpβ) and its downstream de novo lipogenesis (DNL)-related genes are both reduced only in female KO mice. BAT-specific knockdown of ChREBPβ displays decreased DNL-related gene expression and mitochondrial morphological defects followed by reduced BAT thermogenesis in female wild-type mice. Lipidomics reveals that, PGC-1α increases ether-linked phosphatidylethanolamine (PE) and cardiolipin(18:2) Show less