This study aimed to identify new genes associated with CRC in patients with normal mismatch repair (MMR) protein expression. Whole-genome sequencing (WGS) was performed in seven early-age-onset Malay Show more
This study aimed to identify new genes associated with CRC in patients with normal mismatch repair (MMR) protein expression. Whole-genome sequencing (WGS) was performed in seven early-age-onset Malay CRC patients. Potential germline genetic variants, including single-nucleotide variations and insertions and deletions (indels), were prioritized using functional and predictive algorithms. An average of 3.2 million single-nucleotide variations (SNVs) and over 800 indels were identified. Three potential candidate variants in three genes- This study provides a new spectrum of insights into the potential genes, variants and pathways associated with CRC in Malay patients. Show less