Genome-wide association studies implicate common genetic variations in the Fine mapping analyses included Bayesian colocalization to identify the most likely causal variant. Human induced pluripotent Show more
Genome-wide association studies implicate common genetic variations in the Fine mapping analyses included Bayesian colocalization to identify the most likely causal variant. Human induced pluripotent stem cells were genome-edited using CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR associated protein 9) to delete or modify candidate enhancer regions and generate Multitrait colocalization analyses pointed at rs11172113 as the most likely causal variant in Our findings support allele-specific Show less