To investigate correlations between the levels of uric acid and apo-E in patients with normo- and hyperlipidemia. Serum lipids, apolipoprotein spectrum and uric acid levels were measured with Chronola Show more
To investigate correlations between the levels of uric acid and apo-E in patients with normo- and hyperlipidemia. Serum lipids, apolipoprotein spectrum and uric acid levels were measured with Chronolab (Switzerland) kits in 78 patients: 58 with normolipidemia and 25 patients with hyperlipidemia of type IIa and IIb. Significantly higher levels of apo-E were registered in patients with hyperlipidemia than in patients with normolipidemia, but there were no differences by content of uric acid. A comparative correlation analysis detected a significant correlation between uric acid levels and apo-E in both groups but in normolipidemic patients the correlation was positive while in hyperlipidemic patients it was negative. Hyperlipidemia provokes inversion of correlation between the levels of uric acid, apo-E and apo-C3. A rise of apo-C3 may serve an adaptive mechanism of inhibition of apo-E induced hyperlipidemia. Show less
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