Machiavellianism and borderline personality are known for influencing interpersonal dynamics through manipulative behaviors. Machiavellianism is characterized by calculated, egotistic, and callous man Show more
Machiavellianism and borderline personality are known for influencing interpersonal dynamics through manipulative behaviors. Machiavellianism is characterized by calculated, egotistic, and callous manipulation, while borderline personality involves emotionally driven impulsive manipulation due to instability and fear of abandonment. In this study, we explored the relationships of the two constructs with respect to broader personality constructs. Adult participants (N = 1011; Mage = 49.08 years, SD = 17.15) completed two measures each for Machiavellianism and borderline personality and a single inventory measuring the Big Five personality traits. Latent Profile Analysis (LPA) was used to investigate subgroups within the data. Machiavellianism was more strongly negatively associated with agreeableness and conscientiousness, while borderline personality traits were more strongly linked to neuroticism (more positively), agreeableness, and conscientiousness (both more negatively). Two distinct latent profiles emerged. Based on these findings, we suggest that Machiavellianism can align with either adaptive or maladaptive functioning, whereas a combination of Machiavellianism and borderline personality traits underscores a tendency towards manipulative behaviors with emotional instability. We suggest that future research build upon our findings by investigating concrete manipulative acts predicted by borderline personality and Machiavellianism. Show less
Asymmetric delivery and distribution of macromolecules are essential for cell polarity and for cellular functions such as differentiation, division, and signaling. Injury of podocytes, which are polar Show more
Asymmetric delivery and distribution of macromolecules are essential for cell polarity and for cellular functions such as differentiation, division, and signaling. Injury of podocytes, which are polarized epithelial cells, changes the dynamics of the actin meshwork, resulting in foot process retraction and proteinuria. Although the spatiotemporal control of specific protein-protein interactions is crucial for the establishment of cell polarity, the mechanisms controlling polarity-dependent differentiation and division are incompletely understood. In this study, yeast two-hybrid screens were performed using a podocyte cDNA library and the polarity protein PATJ as bait. The protein KIBRA was identified as an interaction partner of PATJ and was localized to podocytes, tubular structures, and collecting ducts. The last four amino acids of KIBRA mediated binding to the eighth PDZ domain of PATJ. In addition, KIBRA directly bound to synaptopodin, an essential organizer of the podocyte cytoskeleton. Stable knockdown of KIBRA in immortalized podocytes impaired directed cell migration, suggesting that KIBRA modulates the motility of podocytes by linking polarity proteins and cytoskeleton-associated protein complexes. Show less