Elahe A Mostaghel, Ailin Zhang, Susana Hernandez+16 more · 2019 · Clinical cancer research : an official journal of the American Association for Cancer Research · added 2026-04-24
Tumor androgens in castration-resistant prostate cancer (CRPC) reflect We evaluated tumor growth and androgens in LuCaP35CR and LuCaP96CR xenografts in response to adrenalectomy (ADX). We assessed pro Show more
Tumor androgens in castration-resistant prostate cancer (CRPC) reflect We evaluated tumor growth and androgens in LuCaP35CR and LuCaP96CR xenografts in response to adrenalectomy (ADX). We assessed protein expression of key steroidogenic enzymes in 185 CRPC metastases from 42 patients. Adrenal glands of intact and castrated mice expressed CYP17A. Serum DHEA, androstenedione (AED), and testosterone (T) in castrated mice became undetectable after ADX (all Mice are appropriate for evaluating adrenal impact of steroidogenesis inhibitors. A subset of ADX-resistant CRPC tumors demonstrate Show less