Brain-derived neurotrophic factor (BDNF) is crucial for brain development, neuronal function, and metabolism. This systematic review aims to comprehensively examine the impact of various diets on BDNF Show more
Brain-derived neurotrophic factor (BDNF) is crucial for brain development, neuronal function, and metabolism. This systematic review aims to comprehensively examine the impact of various diets on BDNF levels, addressing gaps in understanding diet's influence on BDNF's role in neuroprotection and metabolism. This systematic review was conducted in accordance with PRISMA 2020 guidelines. An extensive search was conducted in PubMed, Web of Science, and Scopus up to April 2024, using terms related to diet and BDNF. Relevant clinical trials involving adults were included. Data extraction covered study design, participant details, and outcomes, with quality assessed using the Cochrane method. Clarifications from authors were sought as needed to ensure comprehensive analysis. This review examined 7633 articles to assess the impact of various diets on BDNF levels, narrowing down to 13 studies. The study found varying effects: intermittent fasting and ketogenic diets generally increased BDNF, while other diets showed minimal or no impact. The review highlights diverse outcomes and the need for further research on dietary effects on BDNF. The review found that fasting and calorie restriction diets generally increase BDNF levels, while other dietary interventions showed inconsistent effects. Further research is needed to better understand these dietary impacts on BDNF and to develop optimized strategies for enhancing cognitive health and managing obesity. Show less
Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl ester from HDL-C to LDL-C and VLDL-C. The aim of the present trial was to evaluate the effect of curcumin and its modifie Show more
Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl ester from HDL-C to LDL-C and VLDL-C. The aim of the present trial was to evaluate the effect of curcumin and its modified formulation on serum CETP concentrations in patients with metabolic syndrome. Participants were randomly allocated to one of three groups of 40 subjects receiving either unmodified curcumin or its phospholipid complex or placebo. Lipid profile and plasma CETP were measured at the start and six weeks after initiation of the treatment. The normality of data distribution was assessed by Kolmogorov-Smirnov test. Wilcoxon test was used for comparing the data before and after the intervention. The percent changes of CETP and biochemical factors among the three groups were compared using Kruskal-Wallis test. Serum CETP levels were not significantly altered among patients receiving curcumin. Curcumin and its complex had no significant effect on serum CETP concentrations. Show less