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Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin.

H Takahashi, H Nomura, H Iriki +17 more · 2021 · Science immunology · Science · added 2026-04-24

H Takahashi, H Nomura, H Iriki, A Kubo, K Isami, Y Mikami, M Mukai, T Sasaki, J Yamagami, J Kudoh, H Ito, A Kamata, Y Kurebayashi, H Yoshida, A Yoshimura, H W Sun, M Suematsu, J J O'Shea, Y Kanno, M Amagai Show less

Interleukin-27 (IL-27) is an immunoregulatory cytokine whose essential function is to limit immune responses. We found that the gene encoding cholesterol 25-hydroxylase (Ch25h) was induced in CD4

📄 PDF DOI: 10.1126/sciimmunol.abb6444

IL27

👤 K Isami

Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin.