👤 Takashi Hitsumoto

A significant association between lower preheparin serum lipoprotein lipase mass (pre-LpL mass) and coronary artery disease (CAD) has been reported in several clinical studies. However, the predictor of a pre-LpL mass as a CAD event in patients with chronic kidney disease (CKD) remains unclear. This prospective study aimed to investigate the clinical significance of a pre-LpL mass as a predictor of primary CAD events in patients with CKD. A total of 480 CKD patients who did not develop CAD among outpatients who visited the clinic were enrolled. Using receiver operating characteristic curve analysis for a primary CAD event, participants were divided into two groups (low pre-LpL mass (group L, n = 211) or high pre-LpL mass (group H, n = 269)) by pre-LpL mass, and significance of a pre-LpL mass as a predictor for the primary CAD events was performed. At baseline, skin autofluorescence, an indicator of advanced glycation end products The prospective study showed that a decrease in pre-LpL mass is a useful predictor of a primary CAD event in patients with CKD. Additionally, background factors such as an increase in advanced glycation end products and inflammation are also an important factor in these patients. Show less

The cardio-ankle vascular index (CAVI) is a physiological marker that indicates systemic arterial stiffness, and several reports have demonstrated its usefulness as a predictor of cardiovascular disease (CVD). However, there have been no studies examining the clinical significance of CAVI limited to elderly patients with obesity. This prospective study aimed to determine the clinical significance of CAVI as a CVD risk factor in Japanese elderly patients with obesity. This study included a total of 402 Japanese elderly patients with obesity (mean age ± standard deviation: 72 ± 5 years; mean body mass index ± standard deviation: 27.6 ± 2.2 kg/m Group H showed a significantly higher visceral fat area, as measured by abdominal computed tomography, compared to group L. A significant relation with biomarkers, such as homeostasis model assessment of insulin resistance (HOMA-IR); preheparin serum lipoprotein lipase mass (pre-LPL mass) concentration, one of the coronary risk factors; and urinary 8-iso-prostaglandinF2α (U-8-iso-PGF2α) concentration, an indicator of oxidative stress The results of this study indicated that the CAVI increases in the presence of visceral fat accumulation and is significantly associated with key CVD risk factors, such as insulin resistance, low pre-LPL mass, and elevated oxidative stress in Japanese elderly patients with obesity. Furthermore, high CAVI is considered a useful predictor of primary CVD events in such patients. Show less