Hyperlipidemia is characterized by an abnormally elevated serum cholesterol, triglycerides, or both. The relationship between an elevated level of LDL and cardiovascular diseases is well-established. Show more
Hyperlipidemia is characterized by an abnormally elevated serum cholesterol, triglycerides, or both. The relationship between an elevated level of LDL and cardiovascular diseases is well-established. Cholesteryl ester transfer protein (CETP) is an enzyme that moves cholesterol esters and triglycerides between LDL, VLDL, and HDL. CETP inhibition leads to a reduction in cardiovascular disease by raising HDL and minimizing LDL. This study synthesized ten meta-chlorinated benzene sulfonamides 6a-6j and explored their structure-activity relationship. The synthesized molecules were characterized using Based on It was found that a chloro moiety at the ortho-position, or a nitro group at the meta and para-positions, improves the CETP inhibitory activity of synthesized analogs. Computational studies suggest the formation of stable ligand-protein complexes between compounds 6a- 6j and CETP. Show less
A library of 39 amino-benzoxazole derivatives, selected from 57 benzoxazole compounds in the NCI database, was evaluated for their potential as KDR inhibitors using computational docking methods, incl Show more
A library of 39 amino-benzoxazole derivatives, selected from 57 benzoxazole compounds in the NCI database, was evaluated for their potential as KDR inhibitors using computational docking methods, including CDocker, LibDock, and AutoDock Vina. At a screening concentration of 100 µM, 11 compounds demonstrated over 40% KDR inhibition, with six showing notable activity. The IC50 values of the top six compounds ranged from 6.855 to 50.118 µM, with compound 1 showing the highest inhibitory activity (IC Show less