The nuclear hormone receptors liver X receptor Ī± (LXRĪ±) and peroxisome proliferator-activated receptor Ī³ (PPARĪ³) play key roles in the development of fatty liver. To determine the link between hepatic Show more
The nuclear hormone receptors liver X receptor Ī± (LXRĪ±) and peroxisome proliferator-activated receptor Ī³ (PPARĪ³) play key roles in the development of fatty liver. To determine the link between hepatic PPARĪ³ and LXRĪ± signaling and the development of fatty liver, a LXRĪ±-specific ligand, T0901317, was administered to normal OB/OB and genetically obese (ob/ob) mice lacking hepatic PPARĪ³ (PparĪ³(ĪH)). In ob/ob-PparĪ³(ĪH) and OB/OB-PparĪ³(ĪH) mice, as well as ob/ob-PparĪ³(WT) and OB/OB-PparĪ³(WT) mice, the liver weights and hepatic triglyceride levels were markedly increased in response to T0901317 treatment. These results suggest that hepatic PPARĪ³ and LXRĪ± signals independently contribute to the development of fatty liver. Show less