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The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1

Diane Ly, Anjila Dongol, Peter Cuthbertson +8 more · 2020 · Purinergic signalling · Springer · added 2026-04-24

Diane Ly, Anjila Dongol, Peter Cuthbertson, Thomas V Guy, Nicholas J Geraghty, Reece A Sophocleous, Lucia Sin, Bradley J Turner, Debbie Watson, Justin J Yerbury, Ronald Sluyter Show less

The ATP-gated P2X7 ion channel has emerging roles in amyotrophic lateral sclerosis (ALS) progression. Pharmacological blockade of P2X7 with Brilliant Blue G can ameliorate disease in SOD1

no PDF DOI: 10.1007/s11302-020-09692-4

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👤 Reece A Sophocleous

The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1