Opeyemi B Ogunsuyi, Tosin A Olasehinde, Ganiyu Oboh · 2022 · Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · Taylor & Francis · added 2026-04-24
We investigated the effect of African eggplant (AE) ( Transgenic flies expressing human Amyloid Precursor Protein (hAPP) and β-secretase (hBACE 1) were exposed to the pulverised leaf samples (0.1 and Show more
We investigated the effect of African eggplant (AE) ( Transgenic flies expressing human Amyloid Precursor Protein (hAPP) and β-secretase (hBACE 1) were exposed to the pulverised leaf samples (0.1 and 1.0%) in their diets for fourteen days. Thereafter, the flies were assessed for their behavioural indices and routine histology of brain cells. Furthermore, fly head homogenates were assayed for β-amyloid level, activities of acetylcholinesterase (AChE) and β-secretase (BACE-1), as well as oxidative stress markers. Result showed that the significantly lower ( This study has showed that leaves of AE and BN ameliorated behavioural and biochemical indices in AD flies via neural enzyme modulatory, and antioxidant mechanisms. Hence, this study further justifies the neuroprotective properties of both AE and BN. Show less