Stefano Brunelli, Sami Nourbakhsh, Lorenzo Grimaldi+10 more · 2025 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · Springer · added 2026-04-24
Evaluate the association between functional recovery and a panel of specific neuronal biomarkers, in a cohort of stroke patients. Serum levels of neuronal specific enolase (NSE), neurofilament light c Show more
Evaluate the association between functional recovery and a panel of specific neuronal biomarkers, in a cohort of stroke patients. Serum levels of neuronal specific enolase (NSE), neurofilament light chain (NfL), brain derived neurotrophic factor (BDNF), amyloid-β Linear regression was performed to predict changes in clinical scales during follow up, according to baseline biomarkers levels. NSE at T0 was a significant predictor of improvement in FAC and RMI, where the higher the NSE concentration, the smaller the improvement. Therefore, baseline NSE explained 39% of the variation in FAC and 31% in RMI over time. No significant differences were observed with respect to other scales or other biomarkers. This exploratory study suggested that serum NSE may be a predictor of functional mobility recovery in post-acute stroke patients and represents a useful tool for patients' stratification. Show less