Alzheimer's disease is the most common neurodegenerative disease with therapeutic limitations. Insulin resistance plays a role in the progression of Alzheimer's disease. Therapies that modulate insuli Show more
Alzheimer's disease is the most common neurodegenerative disease with therapeutic limitations. Insulin resistance plays a role in the progression of Alzheimer's disease. Therapies that modulate insulin secretion and signaling, as well as oxidative stress in the brain are now being investigated for their potential role in the prevention of Alzheimer's disease (AD). Terminalia macroptera (Combretaceae) is a plant that different parts have been used traditionally for the treatment of metabolic and neurological conditions. Previous study has indicated that the crude extract exhibit anti-diabetic property. In addition, the plant is a rich source of tannins, phenolic acids, flavonoids, triterpenes. However, there is no study on its protective effect against biochemical alterations of AD in diabetic rats. The present research study investigated the neuroprotective effects of TeMacā¢ on Alzheimer-like pathology induced by aluminum chloride (AlCl A phytochemical analysis of TeMacā¢ was carried out to quantify tannins. The potential effect of the tannins-enriched fraction (TEF) of TeMacā¢ to prevent the formation of senile plaques was conducted by its ability to inhibit the activities of Ī²-secretase (EC 3.4.23.46), monoamine oxidase A (EC 1.4.3.4) and the fibrillation of AĪ². A diabetic model was induced from female Wistar rats by a single intraperitoneal injection of streptozotocin (STZ, 35Ā mg/kg BW). After that, the blood glucose level was measured to confirm the induction of diabetes. Three days after induction, animals received AlCl TEF of TeMacā¢ displays a potential ability to inhibit the activities of Ī²-secretase, monoamine oxidase, and AĪ² fibrillation. Treatment with TEF of TeMacā¢ significantly inhibited DPP4 and BACE1 activities and reduced brain glucose and amyloid fibril levels, and improved cerebral albumin levels and modulated oxidative stress markers. Our findings indicate that TEF of TeMacā¢ prevents Alzheimer's-type pathology linked to insulin resistance in rats. TEF of TeMacā¢ may be a potential drug candidate for the treatment of diabetes-associated cognitive impairment. Show less