👤 N V Gulyaeva

To evaluate the relationship between the levels of interleukin (IL)-6 (a marker of inflammation), cortisol (a marker of the hypothalamic-pituitary-adrenal axis functioning), and brain-derived neurotrophic factor (BDNF, a key neurotrophic factor) in acute and long-term (after 1 month) periods of traumatic brain injury (TBI) with trauma characteristics, as well as neurological and mental disorders. Analysis of data from a cohort longitudinal prospective study. Changes over time in IL-6, cortisol, and BDNF levels during the 1 month after injury were described: IL-6 and cortisol decreased, while BDNF increased, reflecting mechanisms of primary injury and secondary recovery processes. In the acute period, levels of IL-6, cortisol, and BDNF correlated with the severity of the patient's condition: low BDNF and high IL-6 and cortisol levels were associated with a more severe injury, as assessed by the Glasgow Coma Scale. An association between these markers and the presence of amnesia and abnormal EEG changes in the acute period of TBI was found. IL-6, cortisol, and BDNF are important pathophysiological markers of TBI associated with both immediate features of TBI and its complications. Show less

Benign prostatic hyperplasia is still one of the most important problems of modern urology. We studied the gene expression of androgen metabolic enzymes involved in the synthesis of androgens directly in the target organs in 20 patients using real-time RP-PCR. A significant increase in the mRNA of HSD1 7B3 approximately 1,7 fold, SRD5A2 approximately 2 fold, HSD3B1 approximately 2 fold, STS approximately 2,3 fold u AR -2.5 fold and reduced HSD17B2 approximately 4 fold in samples of tumor tissue compared with adjacent tissues. Show less