Atherosclerosis is often associated with inflammation and non-alcoholic liver disease due to high-cholesterol diet and the side effects of conventional treatment. This study aimed to determine the eff Show more
Atherosclerosis is often associated with inflammation and non-alcoholic liver disease due to high-cholesterol diet and the side effects of conventional treatment. This study aimed to determine the efficacy of Hypercholesterolemia induction was achieved by oral administration of feed with lard for 21 days in male Wistar rats. Next, the animals were treated with 4 mg/kg BW of BBLE (single dose) and 4 mg/kg BW of BBLE+SAE (combined dose) for 3 months, and continued to be given a high cholesterol diet. The negative control was a high cholesterol diet, and the positive control was simvastatin. Blood samples were taken to determine total cholesterol, apolipoprotein-E (Apo-E), interleukin-6, tumor necrosis factor-ฮฑ, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels. Meanwhile, the weight of the liver and histopathology preparations were weighed. Giving BBLE+SAE was able to reduce body weight, liver weight, and cholesterol levels significantly compared to negative controls ( Administration of BBLE+SAE acts as an anti-atherosclerotic and hepatoprotective agent for the liver through reducing pro-inflammatory cytokines, and its use was promising for clinical studies. Show less