In recent years, young adults have navigated multiple, simultaneous crises - COVID-19, war in Ukraine, economic turbulence, climate change, and rapid AI growth - which pose complex mental-health risks Show more
In recent years, young adults have navigated multiple, simultaneous crises - COVID-19, war in Ukraine, economic turbulence, climate change, and rapid AI growth - which pose complex mental-health risks. Drawing on multisystemic resilience models and the dual-factor model of mental health, we examine how individual (emotion-regulation difficulties), relational (attachment, social support), and contextual resources (social engagement, place attachment, socioeconomic status) relate to distinct emotional-response profiles and their change across three waves (July 2023, February 2024, September 2024) in a representative Polish sample ( The online version contains supplementary material available at 10.1186/s12992-026-01199-8. Show less
De novo balanced chromosomal aberrations (BCAs), such as reciprocal translocations and inversions, are genomic aberrations that, in approximately 25% of cases, affect the human phenotype. Delineation Show more
De novo balanced chromosomal aberrations (BCAs), such as reciprocal translocations and inversions, are genomic aberrations that, in approximately 25% of cases, affect the human phenotype. Delineation of the exact structure of BCAs may provide a precise diagnosis and/or point to new disease loci. We report on six patients with de novo balanced chromosomal translocations (BCTs) and one patient with a de novo inversion, in whom we mapped breakpoints to a resolution of 1 bp, using shallow whole-genome mate pair sequencing. In all seven cases, a disruption of at least one gene was found. In two patients, the phenotypic impact of the disrupted genes is well known ( Show less