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New insights into the neuroprotective and beta-secretase1 inhibitor profiles of tirandamycin B isolated from a newly found Streptomyces composti sp. nov.

Thitikorn Duangupama, Jaturong Pratuangdejkul, Sumet Chongruchiroj +8 more · 2023 · Scientific reports · Nature · added 2026-04-24

Thitikorn Duangupama, Jaturong Pratuangdejkul, Sumet Chongruchiroj, Pattama Pittayakhajonwut, Chakapong Intaraudom, Sarin Tadtong, Patcharawee Nunthanavanit, Weerasak Samee, Ya-Wen He, Somboon Tanasupawat, Chitti Thawai Show less

Tirandamycin (TAM B) is a tetramic acid antibiotic discovered to be active on a screen designed to find compounds with neuroprotective activity. The producing strain, SBST2-5

📄 PDF DOI: 10.1038/s41598-023-32043-3

BACE1

👤 Sumet Chongruchiroj

New insights into the neuroprotective and beta-secretase1 inhibitor profiles of tirandamycin B isolated from a newly found Streptomyces composti sp. nov.