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The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets.

Kimberley El, Jonathan D Douros, Francis S Willard +14 more · 2023 · Nature metabolism · Nature · added 2026-04-24
The incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) mediate insulin responses that are proportionate to nutrient intake to facilitate glucose tolerance
📄 PDF DOI: 10.1038/s42255-023-00811-0
GIPR