Adipocytic tumors of the head and neck are mostly benign, but laryngopharyngeal tumors are uncommon and poorly characterized. We compared the clinicopathologic profile of laryngopharyngeal liposarcoma Show more
Adipocytic tumors of the head and neck are mostly benign, but laryngopharyngeal tumors are uncommon and poorly characterized. We compared the clinicopathologic profile of laryngopharyngeal liposarcomas (LP-LPS) and lipomas (LP-L) across two institutions. Head and neck adipocytic tumors were queried for LP-LPS and LP-L. Demographic, pathologic, immunophenotypic features (including LPS constituted 1.4% ( Head and neck LPS are rare but disproportionately represented at laryngopharyngeal sites both as a proportion of head and neck liposarcomas and proportion of adipocytic tumors by site. LP-LPS share similarities to LP-L, and are easily mistaken for SCL, inflammatory or vascular lesions. While atypical hyperchromatic cells are discriminatory between LP-LPS and LP-L, The online version contains supplementary material available at 10.1007/s12105-026-01915-1. Show less