Despite of the highly potent antiretroviral therapies, HIV-1 establishes persistent infection and causes chronic inflammation in AIDS patients. Beyond CD4+ T cells, HIV-1 infects myeloid cells, includ Show more
Despite of the highly potent antiretroviral therapies, HIV-1 establishes persistent infection and causes chronic inflammation in AIDS patients. Beyond CD4+ T cells, HIV-1 infects myeloid cells, including circulating monocytes and tissue-resident macrophages, and integrates with host genomes to form stable viral reservoirs. To achieve a functional HIV cure, latency-promoting agents (LPAs) have been developed for the "block-and-lock" strategy to reinforce deep HIV-1 latency and permanently silence proviruses. However, most LPAs have been tested mainly in CD4 Show less
Diabetes mellitus (DM) increases tuberculosis (TB) susceptibility and worsens outcomes. Since inflammation and lipid metabolism are implicated in both diseases, we examined if combined TB and DM (TB-D Show more
Diabetes mellitus (DM) increases tuberculosis (TB) susceptibility and worsens outcomes. Since inflammation and lipid metabolism are implicated in both diseases, we examined if combined TB and DM (TB-DM) increases inflammation or dyslipidaemia. In plasma from individuals with DM ( Show less