👤 Wioleta Grela

Tobacco smoking, counted as one of the alternating external cardiovascular risk factors, can cause disadvantageous changes of concentration of compounds considered to be the new internal risk factors. The aim of the study was to determine the influence of tobacco smoke on concentration levels of homocysteine, dimethylarginine (ADMA), fibrinogen and C-reactive protein (CRP) in healthy smoking male's blood plasma. 71 healthy male volunteers, aged 30-59, were chosen for the study. Based on a questionnaire they were divided into non-smoking group (37 individuals) and active smokers group (34 individuals). The results obtained indicate the most significant increasing effect of tobacco smoke on blood plasma homocysteine levels (by 11.9%) and then, successively, on fibrinogen (by 10.1%) and ADMA (by 9.1%). Changes of CRP concentration, although differentiated similarly to other factors, were insignificant. Since the coexistence of elevated risk factors shows a synergistic effect on cardiovascular risk level in general, it is advisable to perform tests of new risk factors among people exposed to tobacco smoke. The tests will appoint the ones at risk of disease and help to cover them with a medical care. Show less

Toxic tobacco smoke exposure to human organism is strictly related to progress of atherosclerosis changes. One of the mechanisms of these effects is a change of blood lipoprotein fraction concentrations. The concentrations of the lipid profile parameters (TCL, HDL, LDL, TG) and the chosen biomarkers (urine cotinine and 1-hydroxypyrene and blood carboxyhaemoglobine) were determined. It was studied whether the procedure of the groups determination (nonsmokers, passive and active smokers) affect the calculated average values of lipid profile parameters. The role of the applied biomarkers for the detection of the effects related to the tobacco smoke exposure is also discussed. It is concluded that there is no difference among the lipid profiles of passive smokers and nonsmokers. Cigarette smoking increases and lowers the TG and HDL concentrations, respectively. Urine cotinine seems to be the best indicator of tobacco smoke exposure among three chosen biomarkers. Study subjects were 300 male and female volunteers. Show less

Toxic effects of tobacco smoke may manifest by the increase of concentration of aterogenic compounds in the human body. One of them is asymmetric dimetyloarginine (ADMA) which is perceived not only as a significant risk factor of endothelium dysfunction and cardiovascular disease but also predicts all-cause and cardiovascular mortality independently of established and emerging cardiovascular risk factor. The aim of this work was to check to what degree ADMA concentration in plasma changes for people exposed to tobacco smoke in various intensity. The study population consisted of 168 healthy males between the age of 18 and 60. The exposure to tobacco smoke in examined groups was determined on the basis of questionnaires and cotinine concentration in plasma. Three groups were selected: non-smokers (53 people), passive smokers (48 people) and active smokers (67 people). Insignificant differences of ADMA concentration between passive and active smokers in relation to non-smokers were determined, 15.4% (0.45 vs. 0.39 mmol/l,) and 7.7% (0.42 vs. 0.39 mmol/l) respectively. There was no significant relationship between concentration of ADMA and cotinine in plasma (r=0.173; p=0.239 for passive smokers and r=0.218; p=0.076 for active smokers). The results obtained indicate that tobacco smoke has small influence on ADMA level in healthy males' plasma. Show less