📚 Article Archive

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction.

Sahar I Da'as, Khalid Fakhro, Angelos Thanassoulas +8 more · 2018 · The Biochemical journal · added 2026-04-24

Sahar I Da'as, Khalid Fakhro, Angelos Thanassoulas, Navaneethakrishnan Krishnamoorthy, Alaaeldin Saleh, Brian L Calver, Bared Safieh-Garabedian, Egon Toft, George Nounesis, F Anthony Lai, Michail Nomikos Show less

The most common inherited cardiac disorder, hypertrophic cardiomyopathy (HCM), is characterized by thickening of heart muscle, for which genetic mutations in cardiac myosin-binding protein C3 (

no PDF DOI: 10.1042/BCJ20180685

MYBPC3

👤 Angelos Thanassoulas

Disparate Molecular Properties of Two Hypertrophic Cardiomyopathy-Associated cMyBP-C Mutants Reveal Distinct Pathogenic Mechanisms Beyond Haploinsufficiency.

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction.