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Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction.

Sahar I Da'as, Khalid Fakhro, Angelos Thanassoulas +8 more · 2018 · The Biochemical journal · added 2026-04-24

Sahar I Da'as, Khalid Fakhro, Angelos Thanassoulas, Navaneethakrishnan Krishnamoorthy, Alaaeldin Saleh, Brian L Calver, Bared Safieh-Garabedian, Egon Toft, George Nounesis, F Anthony Lai, Michail Nomikos Show less

The most common inherited cardiac disorder, hypertrophic cardiomyopathy (HCM), is characterized by thickening of heart muscle, for which genetic mutations in cardiac myosin-binding protein C3 (

no PDF DOI: 10.1042/BCJ20180685

MYBPC3

👤 Bared Safieh-Garabedian

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction.