📚 Article Archive

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension.

Morgane Baron, Julie Maillet, Marlène Huyvaert +28 more · 2019 · Nature medicine · Nature · added 2026-04-24

The G-protein-coupled receptor accessory protein MRAP2 is implicated in energy control in rodents, notably via the melanocortin-4 receptor

📄 PDF DOI: 10.1038/s41591-019-0622-0

MC4R

Study of monogenic forms of obesity has demonstrated the pivotal role of the central leptin-melanocortin pathway in controlling energy balance, appetite and body weight

👤 Raphaël Boutry

Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension.

Loss-of-function mutations in ADCY3 cause monogenic severe obesity.