A paternal high-fat diet (HFD) has been shown to affect the expression of peroxisome proliferator-activated receptors ( In this experimental study, adult male Wistar rats (F0) were fed for 60 days wit Show more
A paternal high-fat diet (HFD) has been shown to affect the expression of peroxisome proliferator-activated receptors ( In this experimental study, adult male Wistar rats (F0) were fed for 60 days with one of the following four diets: control diets (C), control diets with trans fatty acids (CTH), diets containing vitamin E (E) and diets containing vitamin E and trans fatty acids (ETH). Then the male offspring (F1) were raised on standard chow, and their testicular tissue was later analyzed to assess the impact of paternal diet on gene expression, and the expression of the The data revealed that paternal HFD can suppress the expression of Our findings demonstrate the metabolic impact of paternal diet on offspring's, with focus on mechanisms related to altered lipid metabolism and reproductive health. Show less